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Iron overload is closely related to insulin resistance, decreased glucose tolerance, and the occurrence of diabetes mellitus

AMPK also inhibits lipid biosynthesis by suppressing transcription factor sterol regulatory element-binding protein 1 (SREBP1) and promoting the action of peroxisome proliferator-activated receptor alpha (PPAR), a nuclear receptor that acts to enhance both mitochondrial and peroxisomal FA -oxidation 23

It remains elusive how steatotic livers become hypersensitive to ischemia/reperfusion (I/R) injury during liver resection and transplantation

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In addition, it has also been documented to have pro-thyroid benefits as it increases iodine uptake into the thyroid gland and enhances thyroid peroxidase function

Mitochondrial damage occurs in the early stages of PD and a large body of evidence indicates that the activity of mitochondrial complex was impaired in tissues after the death of PD, and another typical feature of PD was that GSH is selectively depleted from the (Liddell and White, 2018)